| Poz. | Igrač | Datum rodjenja | Utak. | Klub |
|---|---|---|---|---|
| GK | Juan Castillo | 17 April 1978 (aged 32) | 11 |  Deportivo Cali |
| GK | Fernando Muslera | 16 June 1986 (aged 23) | 4 |  Lazio |
| GK | Martín Silva | 25 March 1983 (aged 27) | 1 |  Defensor Sporting |
| DF | Diego Lugano (c) | 2 November 1980 (aged 29) | 42 |  Fenerbahçe |
| DF | Diego Godín | 16 February 1986 (aged 24) | 37 |  Villarreal |
| DF | Maxi Pereira | 8 June 1984 (aged 26) | 36 |  Benfica |
| DF | Andrés Scotti | 14 December 1974 (aged 35) | 25 |  Colo-Colo |
| DF | Jorge Fucile | 19 November 1984 (aged 25) | 24 | Porto |
| DF | Martín Cáceres | 7 April 1987 (aged 23) | 18 | Juventus |
| DF | Mauricio Victorino | 11 October 1982 (aged 27) | 4 | Universidad de Chile |
| MF | Diego Pérez | 27 September 1982 (aged 27) | 49 |  Monaco |
| MF | Walter Gargano | 27 July 1984 (aged 25) | 27 | Napoli |
| MF | Sebastián Eguren | 8 January 1981 (aged 29) | 26 |  AIK |
| MF | Ignacio González | 1 January 1982 (aged 28) | 20 | Valencia |
| MF | Álvaro Pereira | 28 January 1985 (aged 25) | 18 | Porto |
| MF | Álvaro González | 29 October 1984 (aged 25) | 11 | Nacional |
| MF | Álvaro Fernández | 11 October 1985 (aged 24) | 7 | Universidad de Chile |
| MF | Jorge Rodríguez | 13 January 1985 (aged 25) | 7 | Club Atlético River Plate |
| MF | Nicolás Lodeiro | 21 March 1989 (aged 21) | 3 |  Ajax |
| MF | Egidio Arévalo Ríos | 27 September 1982 (aged 27) | 1 | Peñarol |
| FW | Diego Forlán | 19 May 1979 (aged 31) | 61 | Atlético Madrid |
| FW | Sebastián Abreu | 17 October 1976 (aged 33) | 55 |  Botafogo |
| FW | Luis Suárez | 24 January 1987 (aged 23) | 29 | Ajax |
| FW | Jorge Martínez | 5 April 1983 (aged 27) | 15 | Catania |
| FW | Edison Cavani | 14 February 1987 (aged 23) | 13 | Palermo |
| FW | Sebastián Fernández | 23 May 1985 (aged 25) | 6 |  Banfield |
Najviše utakmica: Rodolfo Rodriguez – 79 utakmica
Najbolji strelac: Hector Scarone – 31 gol
